abstract：OBJECTIVE:To explore the relationships between C-reactive protein (CRP), metabolic syndrome (MetS) and incidence of severe knee or hip osteoarthritis (OA) in a prospective study. METHODS:A population-based cohort (n=5171, mean age 57.5+/-5.9 years) was examined between 1991 and 1994. Data was collected on lifestyle ha...

journal_title：Osteoarthritis and cartilage

authors： Engström G,Gerhardsson de Verdier M,Rollof J,Nilsson PM,Lohmander LS

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The objective of this work was to compare the measurement properties of three categorical X-ray scoring methods for hip osteoarthritis (OA). METHODS:In data obtained from trials and cohorts, radiographs were evaluated using the Kellgren and Lawrence (KL) grading system, the Osteoarthritis Research Society In...

journal_title：Osteoarthritis and cartilage

authors： Gossec L,Jordan JM,Lam MA,Fang F,Renner JB,Davis A,Hawker GA,Dougados M,Maillefert JF,OARSI-OMERACT task force \total articular replacement as outcome measure in OA\.

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To compare synovial glucosamine levels in normal and inflamed equine joints following oral glucosamine administration and to determine whether single dose administration alters standard synovial parameters of inflammation. METHODS:Eight adult horses were studied. On weeks 1 and 2, all horses received 20mg/kg...

journal_title：Osteoarthritis and cartilage

authors： Meulyzer M,Vachon P,Beaudry F,Vinardell T,Richard H,Beauchamp G,Laverty S

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the reproducibility of meniscus T1rho measurements, and to study T1rho relaxation time in the lateral meniscus (LM) and its relationship with adjacent cartilage T1rho in knees with acute anterior cruciate ligament (ACL) injuries at 3T magnetic resonance imaging. METHOD:Qua...

journal_title：Osteoarthritis and cartilage

authors： Bolbos RI,Link TM,Ma CB,Majumdar S,Li X

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To describe the reproducibility and validity of six different measurement techniques for knee subchondral bone mineral density (sBMD). METHODS:A consecutive sample of 50 male and female participants from a population-based longitudinal study had sBMD assessed using dual energy X-ray absorptiometry scans. Ant...

journal_title：Osteoarthritis and cartilage

authors： Dore D,Ding C,Jones G

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to characterize the proteoglycan (PG) production and processing by bone marrow stromal cells (BMSCs) within a tissue engineered construct. METHODS:Bovine BMSCs and articular chondrocytes (ACs) were isolated from an immature calf, seeded into agarose gels, and cultured up to 32 days...

journal_title：Osteoarthritis and cartilage

authors： Connelly JT,Wilson CG,Levenston ME

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:In clinical tissue-engineering-based approaches to articular cartilage repair, various types of flap are frequently used to retain an implanted construct within the defect, and they are usually affixed by suturing. We hypothesize that the suturing of articular cartilage is associated with a loss of chondro...

journal_title：Osteoarthritis and cartilage

authors： Hunziker EB,Stähli A

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that an association exists between the characteristics of the knee adduction moment and foot progression angle (FPA) in asymptomatic individuals and those with mild to moderate and severe knee osteoarthritis (OA). DESIGN:Fifty asymptomatic individuals, 46 patients with mild to moderate...

journal_title：Osteoarthritis and cartilage

authors： Rutherford DJ,Hubley-Kozey CL,Deluzio KJ,Stanish WD,Dunbar M

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Until now there have been no appropriate models for metacarpophalangeal osteoarthritis (OA), even though OA in this joint is a significant medical and economic problem in horses. A good model would be useful to evaluate progression and treatment of OA, particularly in this joint. Therefore, we translated the ...

journal_title：Osteoarthritis and cartilage

authors： Mastbergen SC,Pollmeier M,Fischer L,Vianen ME,Lafeber FP

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To identify differentially expressed genes between axially impacted and control articular cartilage taken from porcine patellae maintained in organ culture for 14 days. METHODS:Porcine patellae were impacted perpendicular to the articular surface to create an impact injury. Intact patellae (control and impac...

journal_title：Osteoarthritis and cartilage

authors： Ashwell MS,O'Nan AT,Gonda MG,Mente PL

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is the most common form of arthritic disease, and it is a major cause of disability and impaired quality of life in the elderly. OA is a complex disease of the entire joint, including bone and cartilage, thereby presenting alternative approaches for treatment. This review summarizes emergi...

journal_title：Osteoarthritis and cartilage

authors： Karsdal MA,Leeming DJ,Dam EB,Henriksen K,Alexandersen P,Pastoureau P,Altman RD,Christiansen C

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum N-telopeptide crosslinks (NTX) over a 6-year interval with the development and progression of radiographically apparent hip osteoarthritis (RHOA) in a community sample of elderly women over 8.3...

journal_title：Osteoarthritis and cartilage

authors： Chaganti RK,Kelman A,Lui L,Yao W,Javaid MK,Bauer D,Nevitt M,Lane NE,Study Of Osteoporotic Fractures Research Group Sof.

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients using meta-analysis on randomized controlled trials (RCTs). METHOD:RCTs from systematic searches were included if they explicitly stated that hip and/or knee OA patients were randomized to eit...

journal_title：Osteoarthritis and cartilage

authors： Christensen R,Bartels EM,Astrup A,Bliddal H

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Calcitonin (CT) has been recently shown to exhibit direct protective effects on articular cartilage against joint degenerative disease. It has been proposed that CT might act via the CT receptor (CTR) to activate the cyclic AMP (cAMP) pathway and protect type II collagen degradation. In this study, we investi...

journal_title：Osteoarthritis and cartilage

authors： Lin Z,Pavlos NJ,Cake MA,Wood DJ,Xu J,Zheng MH

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:To establish an ultrasonographic (US) grading for semiquantitative evaluation of the femoral condylar cartilage of knee osteoarthritis (OA), in vivo, and compare the in vivo US grading with the in vitro US and histologic gradings. DESIGN:Ninety-five patients going to receive total knee arthroplasty because ...

journal_title：Osteoarthritis and cartilage

authors： Lee CL,Huang MH,Chai CY,Chen CH,Su JY,Tien YC

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Insulin-like growth factor-I (IGF-I) is critically involved in the control of cartilage matrix metabolism. It is well known that IGF-binding protein-3 (IGFBP-3) is increased during osteoarthritis (OA), but its function(s) is not known. In other cells, IGFBP-3 can regulate IGF-I action in the extracellular env...

journal_title：Osteoarthritis and cartilage

authors： Hunziker EB,Kapfinger E,Martin J,Buckwalter J,Morales TI

更新日期：2008-02-01 00:00:00

abstract：:Osteoarthritis is primarily characterized by areas of destruction of articular cartilage and by synovitis. Articular damage and synovitis are secondary to local increase of pro-inflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha), enzymes with proteolytic activity (matrix metalloproteinases), and...

journal_title：Osteoarthritis and cartilage

authors： Iovu M,Dumais G,du Souich P

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Articular cartilage is separated from subchondral bone by the tidemark and a calcified cartilage zone. Advancement of the calcified region and tidemark duplication are both hallmarks of osteoarthritis (OA). Currently the mechanisms controlling post-natal articular cartilage mineralization are poorly understoo...

journal_title：Osteoarthritis and cartilage

authors： Jiang J,Leong NL,Mung JC,Hidaka C,Lu HH

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To investigate the potential synergistic and differential effects of cytokine combinations on proteoglycan aggregate catabolism in cartilage. METHODS:Bovine articular cartilage explants were maintained in organ culture and subjected to stimulation with cytokine combinations including interleukin-1alpha (IL-1...

journal_title：Osteoarthritis and cartilage

authors： Durigova M,Roughley PJ,Mort JS

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To examine the effect of beta-aminopropionitrile (BAPN), an inhibitor of lysyl oxidase, on growth and remodeling of immature articular cartilage in vitro. DESIGN:Immature bovine articular cartilage explants from the superficial and middle layers were cultured for 13 days in serum-containing medium with or wi...

journal_title：Osteoarthritis and cartilage

authors： Asanbaeva A,Masuda K,Thonar EJ,Klisch SM,Sah RL

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To determine the specificity and efficiency of the tamoxifen (TM)-induced Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice. METHODS:Col2a1-CreER(T2) transgenic mice were bred with Rosa26 reporter mice. Two-week-old Col2a1-CreER(T2);R26R mice were administered TM for 5 day...

journal_title：Osteoarthritis and cartilage

authors： Zhu M,Chen M,Lichtler AC,O'Keefe RJ,Chen D

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to develop a new technique of gene transfer utilizing radial shock waves. The effects of radial shock waves on gene transfer in rabbit chondrocytes were examined by varying the parameters of exposure conditions in vitro. METHODS:Chondrocytes were obtained from New Zealand white ...

journal_title：Osteoarthritis and cartilage

authors： Murata R,Nakagawa K,Ohtori S,Ochiai N,Arai M,Saisu T,Sasho T,Takahashi K,Moriya H

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to examine the association between patellofemoral (PF) alignment (using standard magnetic resonance imaging (MRI) images of extended knees) and knee pain and function. DESIGN:Subjects were recruited to participate in a natural history study of symptomatic knee osteoarthritis, called ...

journal_title：Osteoarthritis and cartilage

authors： Kalichman L,Zhu Y,Zhang Y,Niu J,Gale D,Felson DT,Hunter D

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of avocado soybean unsaponifiables (ASU) on proinflammatory mediators in chondrocytes and monocyte/macrophage-like cells. DESIGN:To determine the dose response of ASU, chondrocytes (5 x 10(5) cells/well) were incubated at 5% CO(2), 37 degrees C for 72 h with (1) control media alone or...

journal_title：Osteoarthritis and cartilage

authors： Au RY,Al-Talib TK,Au AY,Phan PV,Frondoza CG

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:For many years, the Histologic/Histochemical Grading System (HHGS) for osteoarthritis monitoring has been used as a histological scoring system for the quality of cartilage. There are, however, some limitations using this grading system. The goal of the investigation presented in this paper was to examine the...

journal_title：Osteoarthritis and cartilage

authors： Custers RJ,Creemers LB,Verbout AJ,van Rijen MH,Dhert WJ,Saris DB

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To determine the interrelations between degenerative changes in articular cartilage and underlying trabecular bone during development of osteoarthritis and to test the ability of quantitative magnetic resonance imaging (MRI) to detect those changes. METHODS:Human cadaver patellae were investigated with quant...

journal_title：Osteoarthritis and cartilage

authors： Lammentausta E,Kiviranta P,Töyräs J,Hyttinen MM,Kiviranta I,Nieminen MT,Jurvelin JS

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To evaluate anterior cruciate ligament transection (ACLT) and destabilization of the medial meniscus (DMM) surgical instability models of osteoarthritis (OA) in the 129/SvEv mouse knee joint. DESIGN:Micro-surgical techniques were used to perform ACLT or DMM under direct visualization. Histological scoring wa...

journal_title：Osteoarthritis and cartilage

authors： Glasson SS,Blanchet TJ,Morris EA

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:We present a multi-dimensional framework for the visualization of femoral articular cartilage. The framework comprises methods for visualizing and quantifying changes in cartilage thickness and surface morphology derived from MRI based cartilage segmentation. Adequate visualization of cartilage allows accurat...

journal_title：Osteoarthritis and cartilage

authors： Akhtar S,Poh CL,Kitney RI

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Currently, the surgical treatment of localized cartilage defects has limitations. Alternatively, localized cartilage defects may be treated with small biocompatible metal cartilage tacks. Our purpose was to investigate the applicability of defect-size femoral implants. Different bearing materials, cobalt-chro...

journal_title：Osteoarthritis and cartilage

authors： Custers RJ,Dhert WJ,van Rijen MH,Verbout AJ,Creemers LB,Saris DB

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy, safety and carry-over effect of diacerein, in comparison to piroxicam, in the treatment of Thai patients with symptomatic knee osteoarthritis (OA). DESIGN:This was a double-blind, randomised, piroxicam-controlled, parallel-group study. A 7-day non-steroidal anti-inflammatory drug wa...

journal_title：Osteoarthritis and cartilage

authors： Louthrenoo W,Nilganuwong S,Aksaranugraha S,Asavatanabodee P,Saengnipanthkul S,Thai Study Group.

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is a common complex disease with strong heritable components. In this study, we investigated the association between four putatively functional genetic variants in KLOTHO gene, a strong ageing-related gene, and hand OA in a large female Caucasian population. METHODS:Subjects (n=1015, age ...

journal_title：Osteoarthritis and cartilage

authors： Zhang F,Zhai G,Kato BS,Hart DJ,Hunter D,Spector TD,Ahmadi KR

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To establish the validity of three self-report scales used to measure function following arthroplasty for osteoarthritis (OA) of the carpometacarpal joint. METHOD:Persons with OA of the carpometacarpal joint (n=122) were assessed on one occasion 9-117 months following tendon interposition arthroplasty. They ...

journal_title：Osteoarthritis and cartilage

authors： MacDermid JC,Wessel J,Humphrey R,Ross D,Roth JH

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To determine whether smoking affects knee cartilage in healthy adults by examining the association of tobacco use with tibial cartilage volume and tibiofemoral cartilage defects. METHODS:Two hundred and ninety-seven healthy adult subjects were recruited from an existing cohort examining healthy aging, the Me...

journal_title：Osteoarthritis and cartilage

authors： Racunica TL,Szramka M,Wluka AE,Wang Y,English DR,Giles GG,O'Sullivan R,Cicuttini FM

更新日期：2007-05-01 00:00:00

abstract：:This article has been removed, consistent with Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause. ...

journal_title：Osteoarthritis and cartilage

authors： Martinez I

更新日期：2007-04-27 00:00:00

abstract：OBJECTIVE:Growth factor therapy may be useful for stimulation of cartilage matrix synthesis and repair. Thus, the purpose of our study was to further understand the effect of combined insulin-like growth factor-1 (IGF-1) and osteogenic protein-1 (OP-1) treatment on the matrix synthesized by human adult normal and osteo...

journal_title：Osteoarthritis and cartilage

authors： Chubinskaya S,Hakimiyan A,Pacione C,Yanke A,Rappoport L,Aigner T,Rueger DC,Loeser RF

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Transforming growth factor-beta (TGF-beta) has profound effects on chondrocyte proliferation and matrix production, and dysregulation of TGF-beta action has been implicated in osteoarthritis. The mechanisms by which the diverse actions of TGF-beta are regulated in chondrocytes are unclear. Although it is well...

journal_title：Osteoarthritis and cartilage

authors： Parker WL,Finnson KW,Soe-Lin H,Knaus P,Philip A

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is applied extensively to patients with osteoarthritis of the hip or knee. Previous work has challenged the validity of its physical function scale however an extensive evaluation of its pain scale has not been reported. Our purpose wa...

journal_title：Osteoarthritis and cartilage

authors： Stratford PW,Kennedy DM,Woodhouse LJ,Spadoni GF

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to develop a long-term model of cartilage injury that could be used to compare the effects of radiofrequency energy (RFE) and mechanical debridement as a treatment. METHODS:Partial thickness fibrillation of patellar cartilage was created in 16 mature ponies. Three months after t...

journal_title：Osteoarthritis and cartilage

authors： Edwards RB 3rd,Lu Y,Uthamanthil RK,Bogdanske JJ,Muir P,Athanasiou KA,Markel MD

更新日期：2007-02-01 00:00:00

abstract：INTRODUCTION:The Hip disability and Osteoarthritis Outcome Score (HOOS) was constructed in Sweden; this questionnaire has proved to be valid for persons with hip disability with or without hip osteoarthritis (OA) and with high demands of physical function. OBJECTIVE:The objective of this study was to evaluate the inte...

journal_title：Osteoarthritis and cartilage

authors： de Groot IB,Reijman M,Terwee CB,Bierma-Zeinstra SM,Favejee M,Roos EM,Verhaar JA

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Chondrocytes are highly sensitive to variations in extracellular glucose and oxygen levels in the extracellular matrix. As such, they must possess a number of mechanisms to detect and respond to alterations in the metabolic state of cartilage. In other organs such as the pancreas, heart and brain, such detect...

journal_title：Osteoarthritis and cartilage

authors： Mobasheri A,Gent TC,Nash AI,Womack MD,Moskaluk CA,Barrett-Jolley R

更新日期：2007-01-01 00:00:00